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Research PaperResearchia:202602.21003[Biomedical Engineering > Engineering]

Gaussian surrogates do well on Poisson inverse problems

Alexandra Spitzer

Abstract

In imaging inverse problems with Poisson-distributed measurements, it is common to use objectives derived from the Poisson likelihood. But performance is often evaluated by mean squared error (MSE), which raises a practical question: how much does a Poisson objective matter for MSE, even at low dose? We analyze the MSE of Poisson and Gaussian surrogate reconstruction objectives under Poisson noise. In a stylized diagonal model, we show that the unregularized Poisson maximum-likelihood estimator can incur large MSE at low dose, while Poisson MAP mitigates this instability through regularization. We then study two Gaussian surrogate objectives: a heteroscedastic quadratic objective motivated by the normal approximation of Poisson data, and a homoscedastic quadratic objective that yields a simple linear estimator. We show that both surrogates can achieve MSE comparable to Poisson MAP in the low-dose regime, despite departing from the Poisson likelihood. Numerical computed tomography experiments indicate that these conclusions extend beyond the stylized setting of our theoretical analysis.


Source: arXiv:2602.17274v1 - http://arxiv.org/abs/2602.17274v1 PDF: https://arxiv.org/pdf/2602.17274v1 Original Link: http://arxiv.org/abs/2602.17274v1

Submission:2/21/2026
Comments:0 comments
Subjects:Engineering; Biomedical Engineering
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arXiv: This paper is hosted on arXiv, an open-access repository
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