De novo emergence of metabolically active protocells

A continuous route from a disordered soup of simple chemical feedstocks to a functional protocell -- a compartment that metabolizes, grows, and propagates -- remains elusive. Here, we show that a homogeneous aqueous chemical mixture containing phosphorus, iron, molybdenum salts and formaldehyde spontaneously self-organizes into compartments that couple robust non-equilibrium chemical dynamics to their own growth. These structures mature to a sustained, dissipative steady state and support an organic synthetic engine, producing diverse molecular species including many core biomolecular classes. Internal spherules that are themselves growth-competent are produced within the protocells, establishing a rudimentary mode of self-perpetuation. The chemical dynamics we observe in controlled laboratory conditions also occur in reaction mixtures exposed to natural day-night cycles. Strikingly, the morphology and chemical composition of the protocells in our experiments closely resemble molybdenum-rich microspheres recently discovered in current oceanic environments. Our work establishes a robust, testable route to de novo protocell formation. The emergence of life-like spatiotemporal organization and chemical dynamics from minimal initial conditions is more facile than previously thought and could be a recurring natural phenomenon.

Source: arXiv:2601.11013v2 - http://arxiv.org/abs/2601.11013v2 PDF: https://arxiv.org/pdf/2601.11013v2 Original Link: http://arxiv.org/abs/2601.11013v2